What Is Meloxicam?

Meloxicam is a NSAID (COX-2 Preferential) medication used to manage Osteoarthritis, rheumatoid arthritis, ankylosing spondylitis. This agent is available in both prescription and over-the-counter formulations depending on jurisdiction and indication. The medication has been extensively studied and has a well-established safety and efficacy profile when used appropriately. Healthcare providers often select this agent based on patient-specific factors including comorbidities, concurrent medications, and treatment goals.

Patients should understand that pain management is most effective when combined with non-pharmacological approaches including physical therapy, rest, and lifestyle modifications.

How Meloxicam Works
Meloxicam selectively inhibits cyclooxygenase-2 (COX-2) while sparing COX-1, reducing inflammation and pain with potentially lower GI toxicity than non-selective NSAIDs. However, cardiovascular risks remain a consideration.

Indications

Osteoarthritis, rheumatoid arthritis, ankylosing spondylitis
Acute musculoskeletal pain
Chronic pain conditions
Inflammatory joint diseases
Headaches and migraines (select agents)
Dysmenorrhea
Post-operative pain management

Dosage and Administration

Immediate Release: 7.5-15 mg daily

Maximum Daily Dose: 15 mg daily

Duration: Follow prescribing guidelines and healthcare provider instructions. For over-the-counter use, do not exceed 10 days without consulting a healthcare provider.

Special Populations: Elderly patients and those with renal or hepatic impairment may require lower doses or longer dosing intervals. Consult prescribing information for specific guidance.

Clinical Note
Take with food or milk to minimize GI upset. Do not exceed recommended doses. Report signs of GI bleeding (dark stools, vomiting blood) or allergic reactions immediately. Continue only as long as clinically indicated. Use the lowest effective dose for the shortest duration possible.

Side Effects

Common: Nausea, dyspepsia, abdominal pain, headache, dizziness, drowsiness (muscle relaxants)

Serious but Rare: GI bleeding, perforation, acute kidney injury, cardiovascular events, liver dysfunction, anaphylaxis

Warning
Lower GI risk than non-selective NSAIDs due to COX-2 selectivity, but still carries risk Cardiovascular risk profile similar to other NSAIDs; use with caution in high-risk patients

CARDIOVASCULAR RISK: This medication may increase the risk of heart attack and stroke, especially with long-term use and in patients with cardiovascular risk factors.

GI RISK: Risk of serious gastrointestinal complications including bleeding and perforation, especially in elderly patients, those with ulcer history, and concurrent corticosteroid or anticoagulant use.

RENAL RISK: May cause acute kidney injury, particularly in patients with existing renal impairment, volume depletion, or heart failure.

For muscle relaxants: Use for acute conditions only (typically 2-3 weeks). Do not drive or operate machinery until effects are known.

Contraindications

Post-CABG surgery
Severe renal impairment
Hypersensitivity to NSAIDs
Severe heart failure
Active GI ulcer disease

Drug Interactions

ACE inhibitors: reduced antihypertensive effect
NSAIDs: increased GI and renal risk
Warfarin: increased bleeding risk
Diuretics: reduced effectiveness and hyperkalemia risk
Lithium: increased lithium levels

Key Clinical Evidence

Clinical evidence supports the use of Meloxicam for acute and chronic pain management in appropriate patient populations. Current evidence-based guidelines recommend individualized treatment approaches considering patient comorbidities and risk factors.

Meloxicam: Uses, Dosage & Side Effects

Quick Facts