Acne: Causes, Types & Treatment

A guide to acne vulgaris - the most common skin condition, its types, causes, and effective treatment options

10 min readLast updated: 2026-02-17

Quick Facts

Prevalence
Affects up to 85% of people ages 12-24
Most Common Skin Condition
~50 million Americans affected
Adult Acne
Affects up to 15% of adult women

What Is Acne?

Acne vulgaris is the most common skin condition, affecting nearly 85% of people between ages 12 and 24. It occurs when hair follicles become clogged with oil (sebum) and dead skin cells, leading to whiteheads, blackheads, pimples, or deeper lumps (nodules and cysts). While most common in teenagers, acne can affect people of all ages, including adults.

How Acne Forms
Acne develops through four key processes: (1) excess sebum production stimulated by androgens, (2) abnormal shedding of dead skin cells inside the follicle, (3) colonization by Cutibacterium acnes bacteria, and (4) inflammation. These processes clog pores and create the various types of acne lesions.

Types of Acne Lesions

Non-inflammatory:

  • Whiteheads (closed comedones): Clogged follicles beneath the skin surface
  • Blackheads (open comedones): Clogged follicles open to the surface; the dark color is from oxidized melanin, not dirt

Inflammatory:

  • Papules: Small, red, tender bumps
  • Pustules: Papules with pus at the tip
  • Nodules: Large, solid, painful lumps deep beneath the skin
  • Cysts: Deep, painful, pus-filled lumps that can cause scarring

Causes and Risk Factors

  • Hormonal changes (puberty, menstrual cycles, pregnancy, PCOS)
  • Family history of acne
  • Certain medications (corticosteroids, lithium, androgens)
  • Oily or greasy skincare products and cosmetics
  • Friction or pressure on the skin (helmets, tight clothing, phones)
  • Stress (worsens existing acne)
  • Diet: High glycemic index foods and dairy may worsen acne in some people

Treatment

Mild acne -- topical treatments:

  • Benzoyl peroxide (2.5-10%): Kills bacteria, available over-the-counter
  • Retinoids (adapalene, tretinoin, tazarotene): Unclog pores and prevent new comedones; adapalene 0.1% is available OTC
  • Topical antibiotics (clindamycin, erythromycin): Always used with benzoyl peroxide to prevent resistance
  • Azelaic acid: Anti-inflammatory and antibacterial

Moderate acne:

  • Combination topical therapy (retinoid + benzoyl peroxide + antibiotic)
  • Oral antibiotics (doxycycline, minocycline) for limited courses (3-4 months)

Severe or cystic acne:

  • Isotretinoin (Accutane): Most effective treatment for severe acne; 80-90% cure rate after a typical 4-6 month course
  • Hormonal therapy for women (combined oral contraceptives, spironolactone)
Warning
Isotretinoin is highly effective but has important risks: it is a potent teratogen (causes severe birth defects) and requires strict pregnancy prevention for female patients. Other side effects include dry skin and lips, elevated liver enzymes, and elevated triglycerides. Patients require regular blood monitoring. Discuss all risks and benefits with your dermatologist.
Clinical Note
Effective acne treatment takes time -- typically 6-8 weeks before noticeable improvement. Patients should be counseled about this timeline to promote adherence. Maintenance therapy with a topical retinoid is recommended after clearing to prevent relapse.

Scar Prevention and Treatment

  • Treat acne early and effectively to prevent scarring
  • Do not pick or squeeze acne lesions
  • For existing scars: chemical peels, microneedling, laser resurfacing, dermal fillers, or subcision depending on scar type

When to See a Doctor

See a dermatologist if over-the-counter treatments are not working after 2-3 months, if acne is severe or cystic, if acne is causing scarring, or if acne significantly affects self-esteem or mental health.

Medically reviewed by

Medical Review Team, Dermatology

Last updated: 2026-02-17Sources: 2

The content on Medical Atlas is for informational purposes only. It is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider.

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